Table 3:
Patterns of Medication Use, described in relation to whether child had a prior ICU admission
| Valid % or mean (SD) or median [IQR] | Overall | No Prior ICU Admission | Prior ICU Admission | Unadjusted Odds of prior ICU admission compared to reference cat. a |
|---|---|---|---|---|
| N=160 (72.1%) | N=62 (27.9%) | OR (95% CI), p-value | ||
| Asthma Medication Fills Past 12 Months:£ | ||||
| No Controllers | 27.9% | 30.0% | 22.6% | Reference |
| Monotherapy Controller Therapy | 36.5% | 40.6% | 25.8% | 0.84 (0.38-1.89), p=0.681 |
| Combination Controller Therapy | 35.6% | 29.4% | 51.6% | 2.33 (1.11-4.92), p=0.026 |
| Asthma Medication Prescription Fills Over 12 months Prior to Study Enrollment-Specific type† | ||||
| No Controllers | 27.9% | 30.0% | 22.6% | |
| Monotherapy- Inhaled Corticosteroid (ICS) | 35.6% | 40.0% | 24.2% | |
| Monotherapy- Leukotriene Modifier (LTM) | 0.9% | 0.6% | 1.6% | |
| Combination- ICS+LTM | 23.9% | 20.6% | 32.3% | |
| Combination- ICS+Long Acting Beta Agonist (LABA) | 1.8% | 1.9% | 1.6% | |
| Combination- ICS +LABA+LTM | 9.9% | 6.9% | 17.7% | |
| Rescue Medication Fills | ||||
| Short Acting Beta Agonist (SABA) fills, median (IQR)† | 2.0 (1.0-4.0) | 2.0 (1.0-4.0) | 3.0 (1.0-5.0) | ---- |
| SABA,%≥4 SABA Rx fills† | 32.4% | 28.1% | 43.5% | 1.97 (1.07-3.62), p=0.029 |
| Oral Corticosteroid (OCS) fills, median (IQR) | 1.0 (0.0-2.0) | 1.0 (0.0-2.0) | 1.0 (0.0-2.0) | ---- |
| OCS % ≥2 OCS Rx fills | 35.1% | 33.8% | 38.7% | 1.24 (0.68-2.28), p=0.488 |
| HEDIS AMR, Mean (SD) | 0.45 (0.27) | 0.44 (0.28) | 0.48 (0.24) | 1.05 (0.93-1.17), p=0.447 |
| <0.50 | 47.7% | 48.2% | 46.4% | Reference |
| 0.51-0.69 | 38.1% | 37.6% | 39.3% | 1.09 (0.56-2.13), p=0.811 |
| ≥0.70 | 14.2% | 14.2% | 14.3% | 1.05 (0.41-2.67), p=0.925 |
a
Per one unit increase in HEDIS AMR where value multiplied by 10 prior to input in logistic model (e.g. 0.10 transformed to 1.0 and 0.20 transformed to 2.0: a one unit increase on this scale indicates increase in odds with every 0.10 increase in HEDIS AMR)
†
p<0.05,
£
p<0.01: Distributional difference between prior ICU groups assessed for significance using chi-square test for categorical factors, and for continuous variable t-test when distribution normal and Mann-Whitney U test when departures from normality apparent.