Table 2. Mutation analysis by direct sequencing and GeneScan.
| Dog | TP53 gene mutation | Whole sections (allele frequency; %) |
Divided regions (allele frequency; %) |
Normal cell regions | |||
|---|---|---|---|---|---|---|---|
| Region 1 | Region 2 | Region 3 | Region 4 | ||||
| 1 | c.446_447insAT | Detected (47) | Detected (47) | Detected (43) | Detected (43) | - | ND |
| 2 | c.446_447insAT | Detected (7) | ND (0) | ND (0) | ND (0) | ND (0) | ND |
| c.485G>A | Detected (55) | Detected (55) | Detected (40) | Detected (45) | Detected (50) | ND | |
| 3 | c.446_447insAT | Detected (18) | Detected (39) | ND (0) | ND (0) | ND (0) | ND |
| 4 | c.386C>T | Detected (30) | Detected (15) | Detected (65) | ND (0) | - | - |
| c.446_447insAT | Detected (7) | ND (0) | ND (0) | ND (0) | |||
| c.926A>G | ND | ND | ND | ND | |||
| 5 | c.446_447insAT | Detected (4) | ND (0) | ND (0) | ND (0) | ND (0) | - |
| 6 | c.446_447insAT | Detected (12) | ND (0) | ND (0) | ND (0) | ND (0) | - |
| c.859C>T | ND | ND | ND | ND | ND | ||
| c.1,019A>G | ND | ND | ND | ND | ND | ||
| 7 | c.1,021G>A | ND | ND | ND | ND | ND | - |
| c.1,030G>A | ND | ND | ND | ND | ND | ||
| c.1,033A>G | ND | ND | ND | ND | ND | ||
| c.1,048A>G | ND | ND | ND | ND | ND | ||
| 8 | c.446_447insAT | Detected (9) | ND (0) | ND (0) | ND (0) | ND (0) | - |
ND; Not detected, -; Not examined.