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Depleting CD25+ Tregs reverses skin allograft survival prolonged by shikonin. C57BL/6 mice were transplanted with BALB/C skin and treated with shikonin (40 mg/kg) or CsA (20 mg/kg) for 14 consecutive days or until allograft rejection. They were also depleted of CD4+CD25+ Tregs through injection of anti-CD25 Ab (PC61), as described in the methods. Skin allograft survival times were observed (*P < 0.05 and **P < 0.01, n = 8–9 mice).
