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. 2019 Apr 8;68(Suppl 3):S213–S222. doi: 10.1093/cid/ciy1079

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© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — Chemical structure of delafloxacin with atom numbering for the key positions discussed in the text. Due to the lack of basic group in the C7 substituent, the only ionizable group is the carboxylate function attached to position C3 (calculated pKa = 5.43). The figure shows the calculated predominant forms at pH 7.4 (left; anionic [to 98.5%]) and at pH 5.2 (right; neutral [62.7%]). Calculations were made with MarvinSketch version 18.9.0 (academic license) available from http://www.chemaxon.com.