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. 2019 Apr 8;5(2):00161-2018. doi: 10.1183/23120541.00161-2018

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Copyright ©ERS 2019

This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.

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Effect of double-stranded DNA (dsDNA) oligonucleotide-loaded 1,2-dioleoyloxy-3-(trimethylammonium)propane (DOTAP)-modified poly(dl-lactic-co-glycolic acid) (PLGA) lipid–polymer hybrid nanoparticles (LPNs) on secretion of a) interleukin (IL)-6 and b) IL-8 from NuLi-1 bronchial epithelial cells (BECs). IL-6 and IL-8 were measured in supernatants of NuLi-1 BECs exposed to DOTAP-modified PLGA LPNs loaded with dsDNA oligonucleotides as indicated for 24 h. Lines represent best-fit linear regressions.