Table 1.
Variant genes that were found to be associated with risk of type 2 diabetesa
| Gene symbol | Gene function | Identified by |
|---|---|---|
| CALPN10 | calcium-dependent protease | positional cloning |
| TCF7L2 | transcription factor in Wnt signalling pathway | positional cloning |
| PPARG | transcription factor in adipocyte differentiation | candidate gene approach |
| KCNJ11 | potassium channel regulating insulin secretion | candidate gene approach |
| HHEX | transcription factor | genome-wide association study |
| SLC30A8 | zn transporter in insulin-secreting β-cells | genome-wide association study |
| CDKAL1 | cyclin-dependent kinase associated protein-like 1 | genome-wide association study |
| CDKN2 | cyclin-dependent kinase 2 | genome-wide association study |
| IGF2BP2 | insulin-like growth factor binding protein | genome-wide association study |
| FTO | nucleic acid demethylase (?) | genome-wide association study |
| UBQLNL | ubiquilin 3 | genome-wide association study |
| RALGPS2 | Ral GTP exchange factor | genome-wide association study |
| EGR2 | early growth response 2 | genome-wide association study |
| WFS1 | calcium homeostasis in ER of β-cells | candidate gene approach |