Table 2.
Top 10 signals from the genome-wide analysis of age-adjusted inverse normal AMH in pre-menopausal women
| SNPID | Chr | Pos | EA/OA/EAF | Beta (SE) | P-value | Dir. | Het. P | Imp. qual |
|---|---|---|---|---|---|---|---|---|
| rs16991615 | 20 | 5948227 | A/G/0.068 | 0.26 (0.04) | 3.5 × 10−10 | +++++ | 0.14 | 0.94 |
| rs62236881 | 22 | 29450193 | A/G/0.008 | 0.85 (0.16) | 1.1 × 10−7 | +++?? | 0.77 | 0.84 |
| rs186783371 | 5 | 88062223 | T/A/0.011 | 0.64 (0.12) | 1.4 × 10−7 | ++++? | 0.64 | 0.61 |
| rs35829351 | 11 | 6120686 | G/A/0.449 | 0.11 (0.02) | 2.7 × 10−7 | ++++− | 0.02 | 0.89 |
| rs10732995 | 1 | 175111574 | T/C/0.966 | 0.29 (0.06) | 3.9 × 10−7 | +++++ | 0.86 | 0.93 |
| rs76673357 | 20 | 17831206 | G/T/0.056 | 0.22 (0.04) | 5.0 × 10−7 | +++++ | 0.47 | 0.89 |
| rs7168070 | 15 | 93910220 | T/C/0.329 | 0.11 (0.02) | 5.5 × 10−7 | +++++ | 0.98 | 0.89 |
| rs62237617 | 22 | 28761148 | T/C/0.011 | 0.74 (0.15) | 6.5 × 10−7 | +++?? | 0.89 | 0.82 |
| rs141456816 | 17 | 10362307 | C/T/0.013 | 0.50 (0.10) | 6.7 × 10−7 | ++++− | 0.44 | 0.66 |
| rs6743761 | 2 | 10393228 | A/G/0.482 | 0.09 (0.02) | 2.7 × 10−6 | ++++− | 0.11 | 0.99 |
Beta = difference in mean age-adjusted inverse normal AMH (SD) per allele. Chr = chromosome; Dir. = positive (+) or negative (−) direction of effect in ALSPAC, Sister Study, Generations Study, Nurses’ Health Studies (OncoArray), Nurses’ Health Studies (Illumina) respectively, with “?” indicating that the variant was absent; EA = effect allele; EAF = weighted average effect allele frequency across the studies; Het. P=P-value from Cochrane’s Q-test of heterogeneity of effects across the studies; Imp. qual = mean imputation quality across the studies; Pos = position in hg19/GRCh37; OA = other allele; SE = standard error.