Table 3.
Spontaneous improvement in urinary concentration in the two brothers without identified mutation
| Patient | Presentation |
Last follow-up |
||||
|---|---|---|---|---|---|---|
| Age (months) | Posm (mOsm/kg) | Max Uosm after DDAVP | Age (years) | Posm (mOsm/kg) | Max Uosm after DDAVP | |
| 28.1 | 1.5 | 317 | 114 | 15.3 | 298 | 536 |
| 28.2 | 0.1 | 309 | 91 | 11.5 | 285 | 752 |
Shown are data on urinary concentration. Patient 28.1 presented at the age of 1 month with recurrent vomiting and hypernatraemia. His brother 28.2 was electively reviewed at 3 days of age due to the family history. Both received a clinical diagnosis of NDI based on the inappropriately low urine osmolality. Both showed a spontaneous improvement in symptoms and urinary concentration over time.
Uosm, urine osmolality; Posm, plasma osmolality.