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. 2019 Apr 7;25(13):1566–1579. doi: 10.3748/wjg.v25.i13.1566

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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Comparison of the indices of hepatitis B virus quasispecies complexity between the three groups. A: Incidence-based indices: Number of haplotypes (nHpl), number of mutations (nMuts) (^aP < 0.05, ^bP < 0.01); B: Abundance-based indices: Hill numbers (Hill q = 1 and Hill q = 2) (^cP < 0.05); C: Functional-based indices: Mutation frequency (Mf) and nucleotide diversity (Pi). One outlier value in the CI group was eliminated in the representation of Mf results, but this value was included in the statistical comparisons. nHpl: Number of haplotypes; nMuts: Number of mutations; Mf: Mutation frequency; Pi: Nucleotide diversity; CHD: Chronic hepatitis delta; CHB: Chronic hepatitis B; CI: Hepatitis B virus chronic infection.