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. 2019 Mar 25;374(1772):20180093. doi: 10.1098/rstb.2018.0093

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© 2019 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 4. — SSVs limit CRISPR targeting through shortened genomes. (a) The PI of the combined 2000 and 2010 Mutnovsky population targeting each Mutnovsky SSV plotted against the length of the SSV genome. The number of targeted protospacers located in the core genes (b) or variable genes (c) per kilobase of core or variable genome for each Mutnovsky SSV plotted against its genome length. The values for SSVs with short genomes (smaller than 12 000 bp) and SSVs with long genomes (larger than 14 500 bp) were compared using a two-tailed t-test. n.s., not significant, ***p < 0.001, ****p < 0.0001.