Contingency table of pairwise infections that were predicted to lead to phage escape based on protospacer sequence data. (Single nucleotide polymorphisms (SNPs) in either the seed sequence or PAM were identified, and SNP locations were then compared against the protospacer sequence targeted by the CRISPR array of each clone that phage had been challenged against. These were then compared against the pairwise infections measured in the phenotypic assay. ‘+’ indicates a successful infection, ‘−’ indicates no infection.)