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. 2019 Mar 25;374(1772):20180094. doi: 10.1098/rstb.2018.0094

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© 2019 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 1. — DMS3vir viral titre from 0 to 11 dpi of PA14 WT (a), PA14 ΔmutS (c) or PA14 CRISPR-KO (e) hosts. Bacterial titres during the course of the experiment were also measured for the same hosts (b), (d) and (f), respectively. The average (N = 6) phage (g) and bacterial (h) titres are displayed with error bars that represent 95% confidence intervals (CI). (i) Survival analysis of phage in different host backgrounds over the course of the experiment. (j) The immunity profile for each host at 3 dpi, showing the proportion of bacterial clones that evolved resistance by surface modification (sm) or CRISPR-Cas as well as those that did not evolve resistance (sensitive). Error bars represent 95% CI.