Figure 3.

Hierarchical clustering of CRISPR-Cas systems by their associations with components of DSB-RS. Each square corresponds to the association between a CRISPR-Cas system on the y-axis and a DNA repair pathway in the x-axis. Grey represents no significant association, blue represents a negative association and orange a positive one (Fisher exact test, p < 0.05, median of a 100 likelihood ratio tests less than 0.01). Only systems present in more than 1% and in less than 99% of the total number of genomes in the clade and presented at least one significant associations are represented. Associations in (a) Proteobacteria and (b) in Firmicutes.