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. 2019 Feb 11;115(5):978–988. doi: 10.1093/cvr/cvz021

Figure 4.

Figure 4

MPs increase ROS production in HAEC, which is attenuated by ET-1 receptors antagonism. NADPH-stimulated O2− production was assessed by lucigenin assay in (A) HAEC exposed to total pre-treatment and post-treatment MPs for 5, 15, 30, and 60 min (n = 5–6) and (B) HAEC exposed to post-treatment MPs for 5, 30, and 60 min in presence or absence of BQ123 (ETA antagonist, 1 µmol/L) or BQ788 (ETB antagonist, 1 µmol/L) (n = 5–9). Results represent the mean ± SEM. Data were analysed using one-way ANOVA followed by a post hoc Tukey test. *P < 0.05, **P < 0.01, ***P < 0.001 vs. NS; φP < 0.05 vs. post-treatment.