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. 2018 Jan 11;25(5):267–273. doi: 10.1136/ejhpharm-2017-001411

Table 3.

Potentially inappropriate medications identified on admission during the programme

PIMs type n (%)
Drug indication criteria 84 (25.1)
 Any drug prescribed without an evidence-based clinical indication  59
 Any drug prescribed beyond the recommended duration, where treatment duration is well defined 18
 Any duplicate drug class prescription 7
Cardiovascular system criteria 6 (1.8)
 Amiodarone as first-line antiarrhythmic therapy in supraventricular tachyarrhythmia 4
 Aldosterone antagonists with concurrent potassium-conserving drugs without monitoring of serum potassium 2
Coagulation system criteria 9 (2.7)
 Long-term aspirin at doses greater than 160  mg per day 7
 Aspirin with a past history of peptic ulcer disease without concomitant proton pump inhibitor 2
Nervous system criteria 59 (17.6)
 Benzodiazepines for ≥ 4  weeks 32
 Neuroleptic antipsychotic in patients with behavioural and psychological symptoms of dementia unless symptoms are severe and other treatments have failed 20
 Neuroleptics as hypnotics, unless sleep disorder is due to psychosis or dementia 2
 Prolonged use of first-generation antihistamines 5
Renal system criteria 2 (0.6)
 Digoxin at a long-term dose greater than 125  µg/day if eGFR < 30  mL/min / 1.73  m2 2
Gastrointestinal system criteria 3 (0.9)
 Drugs likely to cause constipation in patients with chronic constipation where non-constipating alternatives are appropriate 3
Respiratory system criteria 2 (0.6)
 Anti-muscarinic bronchodilators with a history of narrow angle glaucoma or bladder outflow obstruction 1
 Benzodiazepines with acute or chronic respiratory failure 1
Drugs that predictably increase the risk of falls in older people 25 (7.5)
 Benzodiazepines 11
 Hypnotic Z-drugs (eg, zolpidem) 14
Analgesic drugs 14 (4.2)
 Use of regular (as distinct from PRN) opioids without concomitant laxative 10
 Long-acting opioids without short-acting opioids for break-through pain 4
Antimuscarinic/anticholinergic drug burden 131 (39.3)
 Concomitant use of two or more drugs with antimuscarinic/anticholinergic properties 131
Total 335 (100)

PIM potentially inappropriate medication, eGFR estimated glomerular filtration rate

HHS Vulnerability Disclosure