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Biodistribution of different PTX and Sun formulations in 4T1.2 tumor-bearing mice. Tissue and organs were harvested 24 h after i.v. administration of (A) Taxol, PTX/PEG5K-Fmoc-NLG2 mixed micelles or PTX+Sun/PEG5K-Fmoc-NLG2 mixed micelles at a PTX dose of 10 mg kg−1 or (B) Sun, Sun/PEG5K-Fmoc-NLG2 mixed micelles or PTX+Sun/PEG5K-Fmoc-NLG2 at a Sun dose of 10 mg kg−1. PTX and Sun concentrations were measured by HPLC-MS. *P<0.05 (vs control, N=3).
