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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Nutr Metab Cardiovasc Dis. 2019 Jan 9;29(3):306–315. doi: 10.1016/j.numecd.2018.12.006

Figure 4. HB-EGF ASO administration improved systemic insulin sensitivity in vivo.

Figure 4.

The male C57BL/6 mice under the Western diet were treated with control or HB-EGF ASOs for four weeks at the dose of 40- and 20mg/kg/week by a 2-week interval (N=5 per group). At four week point After 5 and 3-hour fasting, the glucose and insulin tolerance tests were performed. (C) Body weight change profile during Western diet and ASO administration. (D-E) The circulatory levels of triglyceride and total cholesterol were quantified at four-week point by bleeding 50ul of the blood samples via the retro-orbital route. * p<0.05, ** p<0.01, and *** p<0.001.