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. 2019 Mar 25;2019:1897316. doi: 10.1155/2019/1897316

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Copyright © 2019 Jun Li et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Pretreatment with cholecalciferol inhibits I/R-induced renal cell apoptosis. In the I/R and Chol + I/R groups, mice were conducted with ischemia/reperfusion surgery. In the Chol and Chol + I/R groups, mice were orally administered with three doses of cholecalciferol (25 μg/kg) at 48, 24, and 1 h before I/R surgery. Kidney samples were collected with a 4 h period of reperfusion after ischemia surgery. (a) Renal cell apoptosis was detected by TUNEL assay. Arrows show TUNEL⁺ cells in renal cortical and medullary tubules. Representative photomicrographs were shown from different groups. Original magnification 400x. (b) TUNEL⁺ cells were analyzed. All data were expressed as means ± SEM (n = 6). ^∗∗P < 0.01.