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. 2019 Mar 25;2019:1615925. doi: 10.1155/2019/1615925

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Copyright © 2019 Dafan Yu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ceftriaxone improved synaptic plasticity in hippocampal DG of the CUMS-induced model rats. (a) Immunofluorescent images (1000×) of SYN (green) in the hippocampal DG on the 21st/28th/42nd day. Slices were also treated with BrdU to label new nuclei (blue). Scale bar: 40 μm. (b) Representative transmission electron images of synapses in DG (40000×) were pictured at the three time points. Scale bar: 0.2 μm. (c) Proportion of smile synapses of the CUMS-induced model rats was lower especially on the 42nd day. (d) Thickness of PSD in each synapse was smaller in the CUMS-induced model rats. (e) Average width of the synaptic cleft in synapses of the CUMS-induced model rats was significantly wider. (f) Decreased numbers of vesicles in synapses in the CUMS-induced model rats were reversed by ceftriaxone. ^∗p < 0.05, ^∗∗p < 0.005, ^∗∗∗p < 0.0005, ^∗∗∗∗p < 0.0001, two-way ANOVA (Tukey), n = 3.