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. 2019 Apr 1;10:185. doi: 10.3389/fgene.2019.00185

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Copyright © 2019 Stanfield, Lai, Lei, Johnson, Blanks, Romero, Chance, Mesiano and Koyutürk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Global and hypothesis-driven GSVA pathway enrichment across all studies. (A) Top 30 enriched pathways (by median adjusted p-value) using the hallmark gene sets from MSigDB. (B) Enrichment results for a selected set of pathways from MSigDB related to progesterone response, smooth muscle, inflammation, and cAMP signaling. Heat map is colored by log₂(fold change) where red means up-regulation in laboring samples and blue down-regulation. Rows (gene sets) are clustered using the complete clustering method based on correlation.