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. 2019 Apr 5;15:1744806919837429. doi: 10.1177/1744806919837429

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© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — (a) Mito Stress Test of lumbar DRGs dissected and dissociated on day 10 following the initiation of the five-day bortezomib treatment. Mito Stress Test profile reveals reduced FCCP (4 µM)-induced maximum respiration in the bortezomib group relative to the vehicle-treated group (*P = 0.0147 and ****P < 0.0001, six mice/group). (B) Dissociated lumbar DRGs demonstrate a Glycolysis Stress Test profile where bortezomib group have significantly elevated oligomycin-evoked maximum ECAR relative to the vehicle group (***P = 0.0003 and ****P < 0.0001, six mice/group). Veh: vehicle; Bor: bortezomib; OCR: oxygen consumption rate; ECAR: extracellular acidification rate; Oligo: oligomycin; Rot/AA: rotenone/antimycin A; Gluc: glucose; 2-DG: 2-deoxyglucose; FCCP: ■.