Table 1.
Baseline Characteristics.
| Overall |
eGFR >60 mL/min/1.73 m2 with moderate albuminuria |
eGFR >60 mL/min/1.73 m2 with severe albuminuria |
eGFR = 45-59.9 mL/min/1.73 m2 |
eGFR = 30-44.9 mL/min/1.73 m2 |
eGFR = 15-29.9 mL/min/1.73 m2 |
eGFR <15a mL/min/1.73 m2 |
|
|---|---|---|---|---|---|---|---|
| % (count) | % (count) | % (count) | % (count) | % (count) | % (count) | % (count) | |
| n | 219 641 | 82 577 | 17 140 | 73 755 | 34 359 | 10 255 | 1555 |
| Age, mean, SD | 65.1 (18.9) | 51.9 (17.6) | 52.1 (18.1) | 75.0 (10.9) | 78.3 (11.2) | 77.8 (13.3) | 71.7 (15.5) |
| Female | 53.4 (117 260) | 50.4 (41 600) | 46.3 (7942) | 55.9 (41 218) | 58.3 (20 017) | 55.7 (5711) | 49.7 (772) |
| Age <65 years | 42.9 (94 176) | 75.7 (62 509) | 75.0 (12 862) | 17.3 (12 750) | 11.5 (3968) | 15.5 (1586) | 32.2 (501) |
| First Nation | 2.5 (5502) | 3.8 (3111) | 5.3 (915) | 1.0 (759) | 1.4 (483) | 2.0 (203) | 3.8 (57) |
| Socioeconomic status | |||||||
| Low-income neighborhood | 26.7 (58 647) | 25.0 (20 606) | 26.2 (4495) | 26.8 (19 773) | 29.5 (10 136) | 30.7 (3148) | 31.4 (489) |
| High-income neighborhood | 15.1 (33 256) | 16.4 (13 525) | 15.1 (2588) | 15.1 (11 197) | 13.2 (4522) | 11.9 (1224) | 12.9 (200) |
| Comorbidities | |||||||
| History of MI | 6.5 (14 337) | 3.1 (2564) | 3.8 (654) | 7.9 (5806) | 11.0 (3780) | 13.1 (1340) | 12.4 (193) |
| History of stroke | 7.1 (15 514) | 3.0 (2511) | 4.2 (723) | 8.8 (6490) | 12.2 (4178) | 14.0 (1438) | 11.2 (174) |
| History of CHF | 16.7 (36 649) | 5.9 (4857) | 8.7 (1468) | 19.8 (14 631) | 31.2 (10 720) | 42.3 (4333) | 39.7 (618) |
| Hypertension | 67.6 (148 571) | 45.4 (37 516) | 51.9 (8895) | 81.4 (60 026) | 90.6 (31 136) | 93.4 (9577) | 91.4 (1421) |
| Diabetes | 32.7 (71 794) | 30.4 (25 119) | 35.0 (5996) | 30.2 (22 260) | 37.4 (12 844) | 46.4 (4753) | 52.9 (822) |
| PVD | 2.8 (6057) | 1.2 (998) | 2.0 (349) | 3.4 (2468) | 4.7 (1597) | 5.3 (548) | 6.2 (97) |
| Dementia | 4.9 (10 785) | 1.7 (1385) | 2.6 (447) | 6.3 (4640) | 9.0 (3102) | 10.5 (1076) | 8.7 (135) |
| Chronic pulmonary disease | 11.8 (25 935) | 8.6 (7118) | 10.3 (1757) | 13.0 (9595) | 15.6 (5351) | 18.1 (1855) | 16.7 (259) |
| Moderate or severe liver disease | 0.3 (539) | 0.1 (103) | 0.2 (36) | 0.3 (201) | 0.4 (143) | 0.5 (52) | 0.3 (4) |
| Metastatic solid tumor | 0.9 (1905) | 0.5 (443) | 0.8 (142) | 0.9 (694) | 1.3 (434) | 1.5 (156) | 2.3 (36) |
| Charlson score ≤1 | 81.9 (179 976) | 91.0 (75 200) | 86.4 (14 801) | 81.1 (59 838) | 70.0 (24 044) | 53.1 (5445) | 41.7 (648) |
| Charlson score 2-3 | 15.4 (33 786) | 8.1 (6712) | 12.2 (2087) | 16.5 (12 169) | 24.5 (8430) | 36.1 (3707) | 43.8 (681) |
| Charlson score >3 | 2.7 (5879) | 0.8 (665) | 1.5 (252) | 2.4 (1748) | 5.5 (1885) | 10.8 (1103) | 14.5 (226) |
| Albuminuria | |||||||
| Severe (KDIGO A3) | 32.6 (71596) | NA | 100.0 (17140) | 4.6 (3397) | 9.5 (3255) | 22.9 (2347) | 46.6 (724) |
| Moderate (KDIGO A2) | 45.6 (100 076) | 100.0 (82 577) | 12.2 (8961) | 17.4 (5965) | 22.6 (2312) | 16.8 (261) | |
| No significant albuminuria (KDIGO A1) | 32.6 (71 596) | NA | NA | 65.8 (48 516) | 55.4 (19 022) | 37.3 (3820) | 15.3 (238) |
| Unmeasured | 9.6 (21 106) | NA | NA | 17.5 (12 881) | 17.8 (6117) | 17.3 (1776) | 21.4 (332) |
| Death without dialysis and/or transplant | 10.4 (22 803) | 4.2 (3440) | 7.7 (1320) | 10.1 (7427) | 19.6 (6732) | 31.6 (3191) | 45.4 (529) |
| Death preceded by dialysis and/or transplant | 0.07 (164) | 0.003 (3) | 0.0 (0) | 0.01 (8) | 0.1 (24) | 0.4 (44) | 5.5 (85) |
| Dialysis only (no death or transplant) during the 1-year follow-up | 0.3 (598) | 0.003 (3) | 0.08 (13) | 0.02 (15) | 0.1 (50) | 1.6 (160) | 23.0 (357) |
| Transplant (irrespective of dialysis) during follow-up | 0.02 (37) | 0.001 (1) | 0.0 (0) | 0.0 (0) | 0.0 (0) | 0.04 (4) | 2.1 (32) |
Note. eGFR = estimated glomerular filtration rate; MI = myocardial infarction; CHF = congestive heart failure; PVD = peripheral vascular disease; KDIGO = Kidney Disease: Improving Global Outcomes.
a
eGFR <15 mL/min/1.73 m2 excludes cohort on dialysis.