Figure 6.

Effects of ERK inhibition on TTX-R resurgent currents in small DRG neurons. Representative TTX-R, slow resurgent currents were recorded from small DRG neurons (a–d). The resurgent currents were elicited by the same voltage protocol as described in Figure 1. DRG neurons-exhibited slow resurgent currents (TTX-R) were chosen to study. ERK inhibitor U0126 (10 µM) and its inactive control U0124 (10 µM) were pretreated for 15 min in culture medium and were maintained in the recording chamber. (a and b) In the presence of U0124, the TTX-R resurgent currents were enhanced by inflammatory mediators (IMs). (c and d) U0126 completely prevented the enhancing effects of inflammatory mediators on the TTX-R resurgent currents. (e) The data were presented as mean ± standard error of the mean. Student’s t-test was used to compare the difference, *P < 0.05 (vs. U0124).