Table 1.
Effects of ERK inhibition on TTX-S resurgent and transient sodium currents in medium neurons.
| U0124 | U0216 | IM+U0124 | IM+U0126 | ||
|---|---|---|---|---|---|
| INaRn (N) | (pA/pF) | 39.6±3.018 (3) | 21.8±2.0#15 (3) | 48.6±3.6*17 (3) | 26.9±3.913 (2) |
| V0.5_mn (N) | (mV) | −38.6±2.218 (3) | −33.2±2.015 (3) | −39.9±1.517 (3) | −37.0±1.913 (2) |
| V0.5_hn (N) | (mV) | −58.7±1.018 (3) | −51.4±3.2#15 (3) | −59.3±1.617 (3) | −59.5±1.813 (2) |
| INaTn (N) | (nA/pF) | 1.13±0.0918 (3) | 0.95±0.0715 (3) | 1.18±0.1217 (3) | 0.95±0.0813 (2) |
Data are expressed as mean ± SEM. Significant level was set at P < 0.05. A level of P < 0.1 is regarded as a high probability event and might indicate a trend change. INaR: resurgent current; n (N): cell number (culture number); V0.5_m: half activation voltage; V0.5_h: half inactivation voltage; INaT: transient current; ANOVA: analysis of variance.
*P < 0.1; Student’s t-test, IM+U0124 versus U0124.
#P < 0.05; post hoc Tukey’s test, one-way ANOVA.