Table 2.
Effects of PKC inhibition on TTX-S resurgent and transient sodium currents in medium neurons.
| DMSO | BIM I | IM | IM+BIM I | ||
|---|---|---|---|---|---|
| INaRn (N) | (pA/pF) | 40.3±2.711 (4) | 45.1±6.810 (3) | 55.8±5.5**19 (4) | 52.1±4.29 (4) |
| V0.5_mn (N) | (mV) | −37.4±2.511 (4) | −40.2±2.410 (3) | −44.7±1.9**19 (4) | −38.9±2.99 (4) |
| V0.5_hn (N) | (mV) | −58.9±0.611 (4) | −58.4±1.310 (3) | −58.6±0.816 (4) | −59.9±1.58 (4) |
| INaTn (N) | (nA/pF) | 1.44±0.0811 (4) | 1.37±0.1310 (3) | 1.30±0.0819 (4) | 1.48±0.139 (4) |
INaR: resurgent current; n (N): cell number (culture number); V0.5_m: half activation voltage; V0.5_h: half inactivation voltage; INaT: transient current; DMSO: dimethyl sulfoxide; BIM I: bisindolylmaleimide I. Data are expressed as mean ± SEM.
**P < 0.05; Student’s t-test, IM versus DMSO.