Table 5.
Effects of ERK inhibition on TTX-R resurgent and transient sodium currents in small neurons.
| U0124 | U0216 | IM+U0124 | IM+U0126 | ||
|---|---|---|---|---|---|
| INaRn (N) | (pA/pF) | 15.2±2.810 (3) | 9.3±2.210 (3) | 30.1±6.9**7 (2) | 20.0±5.99 (2) |
| V0.5_mn (N) | (mV) | −22.3±2.710 (3) | −21.5±2.910 (3) | −30.6±3.3*7 (2) | −24.1±3.29 (2) |
| V0.5_h_TTXSn (N) | (mV) | −70.6±2.410 (3) | −72.1±1.68 (3) | −67.5±1.07 (2) | −68.7±1.09 (2) |
| V0.5_h_TTXRn (N) | (mV) | −34.3±1.910 (3) | −37.9±2.210 (3) | −37.7±1.17 (2) | −40.6±2.69 (2) |
| INaT_TTXSn (N) | (nA/pF) | 0.86±0.1610 (3) | 0.51±0.1110 (3) | 1.24±0.217 (2) | 1.13±0.289 (2) |
| INaT_TTXRn (N) | (nA/pF) | 1.27±0.2310 (3) | 1.21±0.1710 (3) | 1.47±0.247 (2) | 1.25±0.269 (2) |
Data are expressed as mean ± SEM. INaR: resurgent current; n (N): cell number (culture number); V0.5_m: half activation voltage; V0.5_h_TTXS: half inactivation voltage of the TTX-S currents; V0.5_h_TTXR: half inactivation voltage of the TTX-R currents; INaT_TTXS: TTX-S transient current; INaT_TTXR: TTX-R transient current.
*P < 0.1; Student’s t-test, IM+U0124 versus U0124.
**P < 0.05; Student’s t-test, IM+U0124 versus U0124.