Table 6.
Effects of PKC inhibition on TTX-R resurgent and transient sodium currents in small neurons.
| DMSO | BIM I | IM | IM+BIM I | ||
|---|---|---|---|---|---|
| INaRn (N) | (pA/pF) | 32.8±8.812 (3) | 28.4±9.58 (3) | 64.7±11.9**8 (2) | 28.8±8.910 (2) |
| V0.5_mn (N) | (mV) | −31.9±4.010 (3) | −39.0±3.57 (3) | −37.1±4.88 (2) | 35.6±2.29 (2) |
| V0.5_h_TTXSn (N) | (mV) | −72.4±1.98 (3) | −72.6±1.27 (3) | −72.1±1.28 (2) | 73.8±1.29 (2) |
| V0.5_h_TTXRn (N) | (mV) | −35.0±1.410 (3) | −34.3±0.97 (3) | −35.8±1.18 (2) | 35.9±0.99 (2) |
| INaT_TTXSn (N) | (nA/pF) | 1.55±0.2312 (3) | 1.09±0.238 (3) | 1.67±0.258 (2) | 1.30±0.2610 (2) |
| INaT_TTXRn (N) | (nA/pF) | 1.22±0.1612 (3) | 1.01±0.128 (3) | 1.34±0.228 (2) | 1.05±0.1910 (2) |
Data are expressed as mean±SEM. INaR: resurgent current; n (N): cell number (culture number); V0.5_m: half activation voltage; V0.5_h_TTXS: half inactivation voltage of the TTX-S currents; V0.5_h_TTXR: half inactivation voltage of the TTX-R currents; INaT_TTXS: TTX-S transient current; INaT_TTXR: TTX-R transient current; DMSO: dimethyl sulfoxide; BIM I: bisindolylmaleimide I.
**P < 0.05; Student’s t-test, IM versus DMSO.