Table 8.
Effects of PMA on TTX-R resurgent and transient sodium currents in medium neurons.
| 4α-PMA | PMA | ||
|---|---|---|---|
| INaRn (N)n_s+f | (pA/pF) | 21.6±3.110 (4)1 | 22.2±3.16 (3)1 |
| V0.5_mn (N) | (mV) | −42.6±6.69 (3) | −37.8±4.67 (3) |
| V0.5_h_TTXSn (N) | (mV) | −55.0±3.312 (4) | −61.7±3.08 (3) |
| V0.5_h_TTXRn (N) | (mV) | −28.5±2.212 (4) | −30.2±1.88 (3) |
| INaT_TTXSn (N) | (nA/pF) | 1.58±0.2112 (4) | 1.07±0.198 (3) |
| INaT_TTXRn (N) | (nA/pF) | 1.20±0.1112 (4) | 0.92±0.198 (3) |
Data are expressed as mean ± SEM. INaR: resurgent current; n (N): cell number (culture number); n_s + f: number of medium neurons expressing both slow and fast resurgent currents; V0.5_m: half activation voltage; V0.5_h_TTXS: half inactivation voltage of the TTX-S currents; V0.5_h_TTXR: half inactivation voltage of the TTX-R currents; INaT_TTXS: TTX-S transient current; INaT_TTXR: TTX-R transient current; PMA: phorbol myristate acetate.