Table 9.
Effects of PMA on TTX-R resurgent and transient sodium currents in small neurons.
| 4α-PMA | PMA | ||
|---|---|---|---|
| INaRn (N) | (pA/pF) | 15.7±3.712 (3) | 14.8±1.811 (3) |
| V0.5_mn (N) | (mV) | −22.9±0.812 (3) | −23.1±0.612 (3) |
| V0.5_h_TTXSn (N) | (mV) | −64.9±0.812 (3) | −64.8±0.712 (3) |
| V0.5_h_TTXRn (N) | (mV) | −33.7±0.512 (3) | −37.3±1.512 (3) |
| INaT_TTXSn (N) | (nA/pF) | 1.06±0.1412 (3) | 1.42±0.2212 (3) |
| INaT_TTXRn (N) | (nA/pF) | 0.87±0.1212 (3) | 0.59±0.1312 (3) |
Data are expressed as mean±SEM. INaR: resurgent current; n (N): cell number (culture number); V0.5_m: half activation voltage; V0.5_h_TTXS: half inactivation voltage of the TTX-S currents; V0.5_h_TTXR: half inactivation voltage of the TTX-R currents; INaT_TTXS: TTX-S transient current; INaT_TTXR: TTX-R transient current; PMA: phorbol myristate acetate.