Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Time evolution of TTR under ambient nano-ESI conditions showing the sequential addition of 64 Da corresponding to either one zinc or four oxidations. At t = 0 min, the peaks to the right of the apo peak correspond to Zn(II) binding; however, at later times, the mass shifts are attributed to Cys-10 oxidation. The red peaks correspond to the backbone fragmentation of TTR between Cys-10 and Pro-11 which occurs simultaneously with TTR oxidation.
