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. Author manuscript; available in PMC: 2020 Apr 2.
Published in final edited form as: Chem Commun (Camb). 2019 Apr 2;55(28):4091–4094. doi: 10.1039/c9cc00682f

Figure 3.

Figure 3.

(A) Mass spectra of TTR tetramer as a function of time collected on a Waters Synapt G2 equipped with a custom SID cell. (B) The SID products of the [TTR + 15H+]15+ tetramer. Monomers, dimers, and b10/y117 fragments are observed. The b10 fragment is doubly oxidized. (C) A magnified look at the [M + 4H+]4+ monomer of TTR reveals a time dependent oxidation of TTR monomer as well as Zn(II) and 2-mercaptoethanol (ME) binding. [TTR + 15H+]15+ retains the native conformation (Figure S1) and is used for SID to retain higher ion abundances.