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. 2019 Feb 19;116(14):7113–7122. doi: 10.1073/pnas.1820690116

Fig. 6.

Fig. 6.

Rapamycin treatment in CA1-RARα KO mice during EE experience reverses LTP and fear memory to normal levels. (A) SC-CA1 LTP in EE-experienced WT and CA1-RARα KO mice treated with rapamycin (rapa) during an EE experience [one-way ANOVA with Tukey’s multiple comparison test: F(2,23) = 24.80, P < 0.0001, ***P < 0.001]. n/N, number of neurons/number of animals. (B–E) Behavioral quantification of contextual and cued fear conditioning in DMSO- or rapamycin-treated WT and CA1-RARα KO mice with EE experience. n/N, number of mice/number of independent litters. (B) Quantification of contextual memory (two-tailed Mann–Whitney U test with Bonferroni correction: **P < 0.01). ns, not significant. (C) Quantification of cued memory (two-tailed Mann–Whitney U test with Bonferroni correction: **P < 0.01). (D) Quantification of freezing in an altered context. (E) Quantification of memory generalization. All graphs represent mean ± SEM.