Fig. 8.

Keratinocyte differentiation gene signature describes the major differences between HPV⁺ and HPV⁻ HNSCC. Data from HNSCC samples on the TCGA database were determined to be HPV⁺ or HPV⁻ and analyzed for differences in gene expression. Bar chart portrays the ranked −log₁₀(P values) of enriched GO terms among genes down-regulated in HPV⁺ HNSCC. Pie chart displays fraction of total down-regulated genes that fall into selected GO categories.