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Ten OAs of H. pylori VacA determined by cryo-EM. The 2D class average and corresponding 3D reconstruction of each conformation are shown. OA-1 is the hexamer. OA-2a–f are all conformers of the dodecamer, having different relative rotational orientations between the two layers. OA-3 is the heptamer. OA-4 is the tetradecamer. OA-5 is the tridecamer. The percentages and resolutions in the last two rows refer to the final dataset and final maps.
