Fig. 5.

(A) Time-dependent fluorescence images of A2780CIS tumor-bearing mouse after i.v. injection of MNPs. Tissue distributions of cisplatin (B) and MNPs (C) at different time post-i.v. injection. Bl, blood; Bo, bone; H, heart; In, intestine; K, kidney; Li, liver; Lu, lung; Mu, muscle; Sk, skin; Sp, spleen; St, stomach; T, tumor. (D and E) Tumor growth inhibition curves (D) and survival rate (E) of the mice bearing A2780CIS tumors after different treatments (n = 8). ***P < 0.001. (F) TUNEL and H&E staining of the tumor tissues from the mice treated with different formulations. (Scale bar: 200 μm.)