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. 2019 Mar 15;116(14):7077–7082. doi: 10.1073/pnas.1901513116

Fig. 6.

Fig. 6.

Blockade of BLA noradrenergic activity prevents the effect of GR agonist treatment into the PrL on spine morphology changes within the aIC, assessed 24 h after object recognition training. (A) Image of a Golgi-impregnated neuron. (B) Dendrite showing different spine types (100× magnification). (C) Spine densities for long thin, stubby, mushroom, and branched spine types in apical dendrites. Data are presented as the number of spines per micrometer (mean ± SEM) [n = 15–20 cells (from five rats)/group: two-way ANOVA, mushroom spines: RU 28362 F1,69 = 7.72, P = 0.007; propranolol F1,69 = 1.38, P = 0.24; interaction F1,69 = 4.40, P = 0.04; branched spines: RU 28362 F1,69 = 6.40, P = 0.01; propranolol F1,69 = 2.63, P = 0.11; interaction F1,69 = 9.21, P = 0.003]. (D) Spine densities in basal dendrites [n = 15–18 cells (from five rats)/group: two-way ANOVA, mushroom spines: RU 28362 F1,62 = 1.46, P = 0.23; propranolol F1,62 = 1.84, P = 0.18; interaction F1,62 = 5.71, P = 0.02; branched spines: RU 28362 F1,62 = 5.75, P = 0.02; propranolol F1,62 = 2.99, P = 0.09; interaction F1,62 = 4.24, P = 0.04]. **P < 0.01 vs. vehicle; ◆◆P < 0.01 vs. RU 28362 alone.