Table 1.

Number of mature B-cell maligancy cases and controls, Odds Ratios (OR) and 95% Confidence Intervals (CI) distributed by number and timing of rheumatology hospital episodes: HMRN diagnoses 2009 to 2015.

	Diffuse large B-cell lymphoma			Marginal zone lymphoma			Follicular lymphoma			Chronic lymphocytic leukaemia			Multiple Myeloma
	Controls	Cases	OR (95%CI)1	Controls	Cases	OR (95%CI)1	Controls	Cases	OR (95%CI)1	Controls	Cases	OR (95%CI)1	Controls	Cases	OR (95%CI)1
	%	%		%	%		%	%		%	%		%	%
Total	N = 17710	N = 1771		N = 9360	N = 936		N = 7870	N = 787		N = 15800	N = 1580		N = 17600	N = 1760
All episodes up to diagnosis
None	93.3	88.1	1(ref)	93.4	86.9	1(ref)	92.9	90.5	1(ref)	93.3	93.6	1(ref)	93.2	90.3	1(ref)
≥1	6.7	11.9	1.9(1.6–2.2)	6.6	13.1	2.2(1.8–2.7)	7.1	9.5	1.4(1.1–1.8)	6.7	6.4	1.0(0.8–1.2)	6.8	9.7	1.5(1.2–1.8)
1	2.4	3.3	1.5(1.1–2.0)	2.4	4.4	2.0(1.4–2.8)	2.1	2.9	1.5(0.9–2.3)	2.3	2.5	1.1(0.8–1.5)	2.3	3.6	1.7(1.3–2.2)
2	1.1	1.3	1.3(0.8–2.0)	1.1	2.4	2.4(1.5–3.9)	1.1	1.5	1.5(0.8–2.7)	1.1	1.1	1.0(0.6–1.6)	1.0	2.1	2.2(1.5–3.2)
≥3	3.2	7.2	2.4(2.0–3.0)	3.2	6.4	2.2(1.6–2.9)	4.0	5.1	1.3(0.9–1.9)	3.3	2.8	0.8(0.6–1.2)	3.6	3.9	1.1(0.9–1.5)
Excluding episodes within 6 months of diagnosis
None	93.6	89.8	1(ref)	93.7	89.1	1(ref)	93.2	91.6	1(ref)	93.6	94.1	1(ref)	93.6	93.2	1(ref)
≥1	6.4	10.2	1.7(1.4–2.0)	6.3	10.9	1.8(1.5–2.3)	6.8	8.4	1.3(1.0–1.6)	6.4	5.9	0.9(0.7–1.1)	6.4	6.8	1.1(0.9–1.3)
1	2.2	2.3	1.1(0.8–1.5)	2.2	3.4	1.6(1.1–2.4)	2.1	2.2	1.1(0.6–1.7)	2.2	2.3	1.0(0.7–1.5)	2.1	2.3	1.1(0.8–1.5)
2	1.1	1.2	1.2(0.8–1.9)	1.0	1.5	1.6(0.9–2.8)	1.1	1.4	1.3(0.7–2.4)	1.1	0.9	0.8(0.5–1.4)	0.9	1.3	1.4(0.9–2.1)
≥3	3.1	6.7	2.3(1.9–2.8)	3.1	6.0	2.1(1.5–2.8)	3.6	4.8	1.4(1.0–1.9)	3.1	2.7	0.9(0.6–1.2)	3.4	3.3	1.0(0.7–1.3)
Excluding episodes within 12 months of diagnosis
None	93.9	90.2	1(ref)	93.9	89.7	1(ref)	93.5	92.2	1(ref)	93.9	94.3	1(ref)	93.8	93.6	1(ref)
≥1	6.1	9.8	1.7(1.4–2.0)	6.1	10.3	1.8(1.4–2.2)	6.5	7.8	1.2(0.9–1.6)	6.1	5.7	0.9(0.7–1.2)	6.2	6.4	1.0(0.8–1.3)
1	2.2	2.3	1.1(0.8–1.5)	2.2	3.0	1.4(1.0–2.1)	2.0	1.7	0.8(0.5–1.5)	2.1	2.2	1.0(0.7–1.4)	2.1	2.0	1.0(0.7–1.4)
2	1.0	1.2	1.3(0.8–2.0)	1.0	1.7	1.9(1.1–3.2)	1.0	1.5	1.6(0.9–2.9)	1.0	1.0	1.0(0.6–1.6)	0.9	1.4	1.5(1.0–2.3)
≥3	2.9	6.3	2.3(1.8–2.8)	2.9	5.6	2.0(1.5–2.7)	3.5	4.6	1.3(0.9–1.9)	3.0	2.5	0.8(0.6–1.2)	3.2	3.1	1.0(0.7–1.3)