Table S1.
MEDLINE In-Process & Other Non-Indexed Citations and Ovid MEDLINE 1946–present; search conducted on September 14, 2016a
| Search category | ID | Search terms |
|---|---|---|
| Disease | #1 | (“human immunodeficiency virus” OR “HIV”) |
| Intervention | #2 | (“once daily” OR “once a day” OR “QD” OR “single tablet” OR “single pill” OR “one pill” OR “fixed dose combination” OR “co-formulated”) |
| Adherence | #3 | (“adherence” OR “nonadherence” OR “non-adherence” OR “adherent” OR “nonadherent” OR “non-adherent” OR adhere* OR “compliance” OR “noncompliance” OR “non-compliance” OR “compliant” OR “noncompliant” OR “non-compliant”) |
| Viral suppression | #4 | (“viral load” OR “viral suppression” OR “virologic suppression” OR “virologic response” OR “virologic failure” OR “virologic success” OR “virological suppression” OR “virological response” OR “virological failure” OR “virological success” OR “RNA suppression” OR “RNA level” OR “RNA concentration” OR “undetectable” OR “undetectability”) |
| Association | #5 | (compare* OR “comparison” OR associate* OR relate* OR relation* OR correlate* OR “correlation” OR cause* OR “versus” OR “vs” OR “vs.” OR “lead to” OR “leads to” OR “led to”) |
| RCT | #6 | (“clinical trial” OR “clinical trials” OR “randomized controlled trial” OR “randomized controlled trials” OR “randomised controlled trial” OR “randomised controlled trials” OR random* OR enroll* OR “protocol” OR “open-label” OR “single blind” OR “double blind”) |
| Real world | #7 | (“observational” OR “longitudinal” OR “retrospective” OR “prospective” OR “follow up” OR “cohort” OR “insurance” OR electronic medic* OR “claims data” OR “naturalistic” OR “pragmatic” OR “medical records” OR “registry”) |
| Study objectives | ||
| 1. Real-world adherence with STR vs MTR | #8 | #1 AND #2 AND #3 AND #7 |
| 2. Association between adherence and viral outcomes | #9 | #1 AND #3 AND #4 AND #5 AND (#6 OR #7) |
| 3. Comparative effects of STR vs MTR on viral outcomes | #10 | #1 AND #2 AND #4 AND (#6 OR #7) |
| All | #11 | #8 OR #9 OR #10 |
| #12 | Limit 11 to yr=“2013-Current” | |
| #13 | Limit 12 to English language | |
Note:
a
An initial search of MEDLINE In-Process was completed on September 6, 2013 to identify any studies that were relevant to the three objectives that were published between 2006 and 2013.
Abbreviations: HIV, human immunodeficiency virus; MTR, multiple-tablet regimen; RCT, randomized controlled trial; STR, single-tablet regimen.