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. 2019 Apr 4;12:2519–2529. doi: 10.2147/OTT.S195234

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© 2019 Zhou et al. This work is published and licensed by Dove Medical Press Limited

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SIRT1 reinforced NF-κB pathway stimulation in macrophages.

Notes: RAW 264.7 macrophages were transfected with SIRT1 or vector and were subsequently activated utilizing 100 ng/mL LPS and 20 ng/mL IFN-γ for 24 hours. Representative immunoblots (A) and quantitative assessment of phosphorylation level of IKK (B), p65 (C), and IκBα (D) in RAW 264.7 macrophages. Results are displayed as mean ± SEM. **P<0.01 vs corresponding control; ^#P<0.05 vs LPS+ INF-γ-treated vector groups.

Abbreviations: LPS, lipopolysaccharide; IFN, interferon; IKK, IκB kinase; SEM, standard error of mean; Con, control.

SIRT1 reinforced NF-κB pathway stimulation in macrophages.

Notes: RAW 264.7 macrophages were transfected with SIRT1 or vector and were subsequently activated utilizing 100 ng/mL LPS and 20 ng/mL IFN-γ for 24 hours. Representative immunoblots (A) and quantitative assessment of phosphorylation level of IKK (B), p65 (C), and IκBα (D) in RAW 264.7 macrophages. Results are displayed as mean ± SEM. **P<0.01 vs corresponding control; ^#P<0.05 vs LPS+ INF-γ-treated vector groups.

Abbreviations: LPS, lipopolysaccharide; IFN, interferon; IKK, IκB kinase; SEM, standard error of mean; Con, control.