Figure 6. Phenotype modulators.

1. The stochasticity of deposit formation due to phase separation will define the foci size, which in turn will influence the amount of free protein in the cytosol. The abundance of the free protein (or the phase‐separated structure) will ultimately determine the cellular phenotype. The behavior and phenotypic outcome may also be influenced by the molecular structure and properties of the phase‐separated structure (e.g., complex coacervates, liquid droplets).
2. Timeline for the different processes that are important for adaptation/response to an environmental change. Time estimates were obtained from published datasets (e.g., Wang et al, 2002; Belle et al, 2006; Escusa‐Toret et al, 2013).