Exercise increased cortical bone area (A) in both RD- and VEDD-fed mice, but dietary administration had no synergistic effect with exercise. Polar moment of inertia (B), maximum moment of inertia (C), and minimum moment of inertia (D) demonstrated similar patterns. P-values for factors in the 2-factor ANOVA with interaction analysis are shown. Box plots show median, quartiles, and outlier fences for each group.