Skip to main content
. Author manuscript; available in PMC: 2020 Apr 4.
Published in final edited form as: Mol Cell. 2019 Apr 4;74(1):8–18. doi: 10.1016/j.molcel.2019.03.011

Figure 3: Schematic representation of factors potentially influencing PRC2 recruitment or catalytic activity.

Figure 3:

SUZ12 acts as scaffold for the complex, containing a C-terminal VEFS domain binding to EED and EZH2/1 and a N-terminal domain with associated non-core subunits. Chromatin binding is dependent on the N-terminal part of SUZ12, and CGI residence time may be modulated by non-core subunits, transcriptional activity and colocalizing factors including PRC1, H2AK119ub1 and H3K27me3. The catalytic activity of PRC2 may be influenced by non-core subunits and post-translational modifications of histones (H3K27me3, H3K4me3 and H3K36me2/me3).