Table 1a.

Comparison of different DILI causality scoring systems

RUCAM/CIOMS			DDW-J		CDS
Variables	Score	% of total score	Score	% of total score	Score	% of total score
Chronological criteria : 1a From drug start to onset*	+1 to +2	+7.1 to +14,3%	+1 to +2	+5.9 – +11.8%	+1 to +3*,**	+5.9 –+17.6
1b From drug stop to onset*	Incompatible *** to +1	0 to +7.1%	0 to +1	0 – +5.9%	−3 to +3*,**	−17.6 – +17.6
2 Dechallenge	−2 to +3	−14.2 to +21.4%	−2 to +3$	−11.8 to +17.6%	0 to +3	0 – +17.6
4 Competing causes	−3 to +2	−21.3 to +14.3%	−3 to +2	−17.6 to 11.8%	−3 to +3	−17.6 – +17.6
5 Rechallenge	−2 to +3	−14.3% to +21.4%	−2 to +3	−11.8 – +17.6%	+3	0 – +17.6
6 Known Hepatotoxicity	0 to +2	0 to +14.3%	0 to +2	0 – +5.9%	−3 to +2	−17.6 – +11.8
3 Risk Factors	0 to +2	0 to +14.3%	0 to +2	0 – +12.5%	-	-
7 Concomitant medication	−3 to 0	−21.4 to 0%	-	-	-	-
Extrahepatic manifestations	-	-	0 to +1	0 – +5.9%	0 to +3	0 – +17.6
Drug lymphocyte stimulation test	-	-	0 to +2	0 – +11.8%	-	-
Total score	−10 to 14		−5 to 17		−6 to 17**
Assessment in each score
Definite	>8		>8		>17
Probable	6–8		5–8		14–17
Possible	3–5		3–4$		10–13
Unlikely	1–2		1–2$		6–9
Excluded	≤ 0		≤ 0		≤ 6

^*only either of these two categories 1a or 1b is to be counted;

^**the paper states a maximal of 20 points, but as you can only either be on a drug or have stopped it you would only the points of 1a or 1b would be counted resulting in a maximum total of 17 points;

^***in a “updated RUCAM” the incompatible scoring for onset after stop of drug has been eliminated.