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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Curr Opin Gastroenterol. 2019 May;35(3):183–190. doi: 10.1097/MOG.0000000000000526

Table 2:

Studies demonstrating drug specific variation in latency*.

Hepatocellular Cholestatic/
mixed
P-value** Reference
Statins
n=14
153 (0 to 1866)
n=8
153 (0 to 3600)
p=0.913 Russo et al.[38]
Azithromycin
n=10
20 (38 to 65)
n=8
17 (2 to 38)
p=0.887  
Martinez et al. [39]
Cefazolin
n=3
23 (21 to 23)
n=16
20 (6 to 29)
 
p=0.487
 
Alqahtani SA, et al.[40]
Quinolones
n=4
13 (5 to 27)
n=8
2 (1 to 11)
 
p=0.215

Orman ES, et al.[41]
Cyproterone acetate (CPA) n=20
150 (105 to 215)
n=2
150 & 151
 
p=0.866
Bessone F, et al. [42]
Ceftriaxone
n=2
11 & 21
n=13
8 (4 to 14)
 
p=0.229.
Nakaharai K, et al. [43]
*

Latency is measured in days from drug start to abnormal liver tests

**

p-value for hepatocellular injury versus cholestatic injury (defined as R value: ALT times upper limit of normal (ULN) / alkaline phosphatase times upper limit of normal (ULN).