Comparison 2. Withdrawals ‐ placebo‐controlled studies.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 All‐cause withdrawal	22	4617	Risk Ratio (M‐H, Fixed, 95% CI)	1.03 [0.92, 1.16]
2 Adverse event withdrawal	22	4346	Risk Ratio (M‐H, Fixed, 95% CI)	1.38 [1.14, 1.67]
3 Lack of efficacy withdrawal	15	3559	Risk Ratio (M‐H, Fixed, 95% CI)	0.57 [0.37, 0.88]