Gong 2008.
Methods | Multicentre, randomised, double‐blind, placebo‐controlled, parallel groups. No enrichment or imputation method mentioned Forced titration from 300 mg daily to 1800 mg daily over 8 days, then stable dose to 6 weeks |
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Participants | PHN N = 231 Mean age 66 years (± 12), 43% women Mean baseline PI: 6.2/10 (± 1.3) |
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Interventions | Gabapentin 1800 mg daily, n = 109 Placebo, n = 106 Rescue medication: 2 x 100 mg tramadol if required 3 days after reaching maximum dose of gabapentin |
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Outcomes | ≥ 25% and ≥ 50% pain relief PGIC ("mild effective" and "excellent") Sleep Quality of life Adverse events |
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Notes | Oxford Quality Score: R = 1, DB = 2, W = 0, Total = 4 Unknown funding |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Not adequately described. "Patients were randomised to different groups according to their recruitment order", but then refers to "pre‐determined code" |
Allocation concealment (selection bias) | Unclear risk | Not adequately described. "Researchers allocated the treatments according to the pre‐determined code" |
Blinding (performance bias and detection bias) All outcomes | Low risk | "Identical‐appearing capsules containing placebo were used to blind the patients" |
Incomplete outcome data (attrition bias) Efficacy | High risk | Withdrawals (7%) and reasons for withdrawal not given per treatment group. No information about how data from withdrawals contributed to analyses |
Size Efficacy | Unclear risk | 50‐199 participants per treatment arm (106, 109) |