Tai 2002.
Methods | Randomised, double‐blind, placebo‐controlled, cross‐over, no enrichment. No imputation method mentioned Titration to limit of tolerability or maximum 1800 mg over 3 weeks, then stable for remainder of 4‐week period; 2‐week washout then cross‐over |
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Participants | Traumatic spinal cord injury > 30 days. PI before treatment > 4/10 N = 14 (7 participants with data) Age 27‐48 years, 1/7 women |
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Interventions | Gabapentin 1800 mg daily (max) Placebo NSAID, TCA and narcotics allowed for rescue medication as needed |
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Outcomes | Withdrawals | |
Notes | Oxford Quality Score: R = 2, DB = 2, W = 1, Total = 5 Grants from American Academy of Physical Medicine and Rehabilitation and Eastern Paralyzed Veterans Association |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Random distribution table |
Allocation concealment (selection bias) | Unclear risk | Not reported |
Blinding (performance bias and detection bias) All outcomes | Low risk | Capsules with "identical shape and colour" |
Incomplete outcome data (attrition bias) Efficacy | Unclear risk | Imputation not mentioned |
Size Efficacy | High risk | < 50 participants per treatment arm (7/14 with data) |