Fig. 6.

NSC145366 mediates AR and BRCA1 degradation without inducing classical heat shock response. LNCaP cells were incubated with indicated treatments for 48 h. Cell lysates were prepared and Protein levels were quantified in the linear dynamic range of a digital imager. The percentage expression level compared to DMSO is displayed for notable signals. Western blots were performed on a minimum of three independent biological replicates and similar results were observed for all replicates.