Table 4.
Incorporation of the growth factors in fibers for stem cell therapy in wound healing.
| DDS | Method | Growth factor |
Study | Result | Ref. |
|---|---|---|---|---|---|
| Gelatin/poly(L-lactic acid)-co-poly-(ε-capr olactone) nanofiber |
Coaxial electrospinning |
EGF | Human fibroblasts Adipose-derived stem cells |
Complete closure of wound after 9 days |
[126] |
| Activated platelet rich plasma |
Blend electrospinning |
FGF, VEGF, EGF |
In vitro | Rapid cellular infiltration | [128] |
| PELA(PEG-PLA) Poly(ethyleneoxide- co-lactic acid) |
Core-sheath nanofibers |
bFGF | Tested in vitro and in vivo in diabetic rats |
Sustained release of bFGF resulted in complete epithelialization after 4 weeks |
[125] |