Fig 4. A custom study phantom demonstrates T1 + T2 range and resolution for mouse sarcoma imaging.

A 3D-printed phantom was designed to hold tubes containing a range of magnevist (T1) and agarose (T2) concentrations, as well as a resolution insert, and was loaded into a syringe filled with water (A). The T1 sequence used in the preclinical trial demonstrates the range of T1 signal within predetermined magnevist concentrations (B), where dilution factor refers to the dilution of a 1% solution in deionized water. The T2 sequence used in the preclinical trial demonstrates the range of T2 signal within predetermined agarose gel concentrations (C). The resolution insert confirms sufficient resolution of the sequences down to 100um (D). Images shown have not been altered or corrected for bias.